Annex XV of the REACH regulation lays down general principles for preparing Annex XV dossiers to propose and justify (a) harmonised classification and labelling of CMRs, respiratory sensitisers and other effects (b) the identification of a substance as a CMR, PBT, vPvB or a substance of equivalent concern (c) restrictions of the manufacture, placing on the market or use of a substance within the Community. Proposals for restrictions and identification of substances of very high concern can be prepared by a Member State Competent Authority or by the Agency on a request from the Commission. Proposals for harmonised classification and labelling can be prepared by a Member State Competent Authority.