A fairly well-circumscribed discrete focus of granulomatous inflammation, caused by Mycobacterium leprae, which consists chiefly of an accumulation of large mononuclear phagocytic cells in which the cytoplasm seems finely vacuolated (i.e., foam cells); the foamlike character of the macrophages is related to the engulfing of numerous acid-fast organisms. [G. lepros, scaly, + -oma, tumor]
