23 April 2021 Bulletin

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2,4-Dinitrophenol (DNP)

2,4-Dinitrophenol (2,4-DNP, or DNP), molecular formula C₆H₄N₂O_5, is an inhibitor of efficient energy (ATP) production in cells with mitochondria. It uncouples oxidative phosphorylation by carrying protons across the mitochondrial membrane, leading to a rapid consumption of energy without generation of ATP. [1]

2,4-Dinitrophenol is a yellow solid with no known smell. It dissolves slightly in water. When present in water and soil as a pollutant, DNP does not easily evaporate to air. [2]

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