(klÄ-pel´ tra-no-na´) Klippel-Trénaunay-Weber syndrome (klÄ-pel´ tra-no-na´ va´ber) a rare condition usually affecting one extremity, characterized by hypertrophy of the bone and related soft tissues, large cutaneous hemangiomas, persistent nevus flammeus (see port-wine stain ), and skin varices.