a chromosomal disorder that is usually fatal within 2 years; characterized by mental retardation, malformed ears, cleft lip or palate, microphthalmia or coloboma, small mandible, polydactyly, cardiac defects, convulsions, renal anomalies, umbilical hernia, malrotation of intestines, and dermatoglyphic anomalies. SYN: Patau syndrome, trisomy D syndrome.
