APBD (medical condition)

A rare progressive metabolic disorder that starts during adulthood and is characterized by loss of sensation, muscle weakness and wasting, reduced bladder control and dementia. The condition is caused by a metabolic disorder where a deficiency of a particular branching enzyme results in a buildup of certain compounds (polyglucosan bodies) in various parts of the body but especially in the nerves. See also Polyglucosan body disease, adult