disorder characterized by hundreds to thousands of precancerous colonic polyps beginning at about age 16 years. Colon cancer predisposition syndrome (i.e., familial polyposis coli, Peutz-Jeghers syndrome, juvenile polyposis syndrome). Rare disease affecting 1 in 25,000 people; either familial or sporadic; characterized by development of dozens to thousands of hamartomatous (benign) polyps in the stomach.