(MJD) (mah-shah´do zho-sef´) an autosomal dominant neurodegenerative disease first described in families of Portuguese-Azorean descent, having a variety of forms but characterized principally by ataxia, spasticity, distal muscular atrophy, and ocular movement abnormalities. It is a type of spinocerebellar ataxia . Called also Azorean disease .