The submission of specific information to the Agency in accordance with a legislative requirement. The REACH Regulation requires actors in the supply chain (manufacturers, importers, downstream users) to submit the following types of notifications, under certain circumstances: - Notification of a substance in an article - Notification of classification and labelling - Notification of substances for the purposes of product and process orientated research and development - Notification by downstream user of use within the conditions of authorisation granted to an actor up his supply chain - Notification of restart of use by downstream user Notification may also refer to substances notified under Dir. 67/548/EEC.