Paxillin

Paxillin is a signal transducing adaptor protein for CELL MIGRATION that localizes primarily to FOCAL ADHESIONS. It undergoes PHOSPHORYLATION in response to integrin-mediated CELL ADHESION, and interacts with a variety of proteins including VINCULIN; FOCAL ADHESION KINASE; PROTO-ONCOGENE PROTEIN PP60(C-SRC); and PROTO-ONCOGENE PROTEIN C-CRK.

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