Ryanodine Receptor Calcium Release Channel

A tetrameric calcium release channel in the SARCOPLASMIC RETICULUM membrane of smooth muscle cells, acting oppositely to SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES. It is important in skeletal and cardiac excitation-contraction coupling and studied by using RYANODINE. Abnormalities are implicated in ARRHYTHMIA and MUSCULAR DISEASES.

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