in diabetes, a rebound phenomenon of reactive hyperglycemia in response to a preceding period of relative hypoglycemia that has increased secretion of hyperglycemic agents (e.g., epinephrine, norepinephrine, glucagon, cortisol, and growth hormone); described in diabetic patients given too much insulin who developed unrecognized nocturnal hypoglycemia that made them hyperglycemic (suggesting insufficient insulin) when tested the next morning.