Avoid the misspelling transexual. (1) A person with the external genitalia and secondary sexual characteristics of one gender, but whose personal identification and psychosocial configuration are that of the opposite gender; a study of morphologic, genetic, and gonadal structure may be genitally congruent or incongruent. (2) Denoting or relating to such a person. (3) Relating to medical and surgical procedures designed to alter a patient's external sexual characteristics so that they resemble those of the opposite gender.