Vatalanib

An orally bioavailable anilinophthalazine with potential antineoplastic activity. PTK787/ZK 222584 binds to and inhibits the protein kinase domain of vascular endothelial growth factor receptors 1 and 2; both receptor tyrosine kinases are involved in angiogenesis. This agent also binds to and inhibits related receptor tyrosine kinases, including platelet-derived growth factor (PDGF) receptor, c-Kit, and c-Fms. (NCI04)

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