What is Creatine?

Creatine (chemical formula: C4H9N3O2), appears as a white or colourless crystal solid that does not mix well with water. Produced by the liver and kidneys, creatine is present in the muscle tissue of many vertebrates as well as small amounts being present in the blood. It is also found in red meats and fish. 

What is Creatine used for?

Creatine is synthethised and marketed as an exercise and performance supplement. It is one of the most popular sports supplements available for those looking to build muscle mass. Studies show that creatine boosts muscle strength and growth, as well as overall physical performance. As one of the most tested supplements, it is readily available in mainly powder and capsule form. 

Creatine is considered a safe and effective supplement to boost physical strength and performance
Creatine is considered a safe and effective supplement to boost physical strength and performance

Creatine Hazards

The routes of exposure for creatine include; inhalation, ingestion and skin and eye contact. 

Inhalation of creatine may produce irritation and inflammation of the respiratory system. Persons with existing conditions such as chronic bronchitis, emphysema, circulatory or nervous system damage or kidney damage, may incur further damage if inhaled. 

While ingestion of creatine is not classified as “harmful by ingestion”, an excessive dose of creatine can cause nausea and vomiting. Ingestion of insignificant quantities is not thought to be a cause for concern. 

Skin contact with creatine may produce inflammation and irritation that can last longer than a day. Symptoms include; redness, swelling and possible blistering, scaling and thickening of the skin. Entry into the bloodstream through open cuts and wounds may produce other harmful effects. 

Eye exposure can cause irritation characterised by tearing and temporary redness. Temporary vision impairment and other transient eye damage may also result.

Creatine Safety

If inhaled, remove the patient from the contaminated area to the nearest fresh air source. If the patient is not breathing and you are qualified to do so, administer CPR (preferably with a bag-valve mask device). Transport to the hospital without delay.

If swallowed, immediately provide a glass of water to the patient. First aid is generally not required, but if in doubt, seek medical attention. 

If skin exposure occurs, flush the affected skin and hair with running water and soap. Seek medical attention in the event of irritation.

If the chemical is exposed to the eyes, flush the eyes out immediately with fresh running water, remembering to wash under the eyelids. Contact lenses should be removed by a skilled professional. Seek medical attention without delay.

Creatine Safety Handling

Emergency eyewash fountains should be accessible in the immediate area of the potential exposure to the chemical and there should always be adequate ventilation to remove or dilute any air contaminants (install local exhaust if necessary). 

The PPE recommended when handling creatine includes; safety glasses with side shields, chemical goggles, dust respirators, overalls, safety boots and rubber or PVC gloves. A skin cleansing cream and barrier cream are also recommended in the event of skin exposure.

For more information on the safe handling of creatine, refer to your SDS. Click here for a trial of our SDS Management Software or contact us at for more information about our chemicals management solutions. 

Chemwatch has the largest collection of SDS in the world. For a FREE copy of the Chemwatch-authored SDS for Creatine, click the button below.