a congenital syndrome inherited as an autosomal dominant trait involving both ectodermal and mesodermal tissues, which consists of ectodermal dysplasia associated with hypopigmentation of the skin and hair, scanty hair and eyebrows, absence of lashes, nail dystrophy, hypo- and microdontia, ectrodactyly, and cleft lip and palate. Called also ectrodactyly–ectodermal dysplasia–clefting syndrome.