Fetal abnormalities due to the maternal use of valproic acid in anticonvulsant therapy of epilepsy during pregnancy. Common craniofacial anomalies include epicanthal folds, broad nose with a flat bridge, anterverted nostrils, shallow philtrum, a thin upper and thick lower lip. Associated disorders may include developmental delay, neurologic abnormalities congenital heart defects, finger abnormalities, and other defects.