A multiple congenital anomaly syndrome of unusual facies, cleft palate, distal limb hypoplasia, lung maldevelopment, and other variable abnormalities. First considered to be lethal, the syndrome is now known to have a 14% survival rate. The surviving patients are usually retarded. Polyhydramnios in third trimester in about 60% of the cases. Fryns and Pallister-Killian syndromes share some common characteristics.