when both the primary injection of endotoxin-containing filtrate and the secondary injection are given intravenously 24 hours apart, the animal usually dies within 24 hours after the second inoculation; the characteristic lesions in the rabbit include widespread hemorrhages in the lung, liver, and other organs and bilateral cortical necrosis of the kidney. This reaction has no immunologic basis. SYN: Sanarelli phenomenon, Sanarelli-Shwartzman phenomenon.
