Hereditary MHC class I deficiency (medical condition)

A genetic defect involving a deficiency of major histocompatibility complex class I which manifests as poor immunity. This deficiency tends to result in chronic respiratory tract infections and chronic lung disease. A deficiency of class II tends to cause severe combined immunodeficiency which manifests as systemic infections that do not appear in Class I deficiency. See also Defective expression of HLA class 1