LAD 1 (medical condition)

A rare inherited disorder characterized by abnormal neutrophil functioning which reduces the body’s immunity. The abnormal neutrophils are unable to be transported to sites of infection due to their inability to adhere to certain blood vessel components which would normally lead them to the infection site. Infections may be life-threatening as the body is unable to destroy bacteria effectively. Type 1 LAD specifically involves a lack of receptor proteins on the neutrophil which prevents it from adhering. See also Leukocyte adhesion deficiency type 1