term used in the Bethesda system for reporting cervical/vaginal cytologic diagnosis to describe a spectrum of noninvasive cervical epithelial abnormalities; these lesions include the cellular changes associated with human papillomavirus cytopathologic effect and mild dysplasia (cervical intraepithelial neoplasia grade 1).Bethesda system, reactive changes, under change, ASCUS, atypical glandular cells of undetermined significance, under cell.