STAT5 Transcription Factor

A signal transducer and activator of transcription that mediates cellular responses to a variety of CYTOKINES. Stat5 activation is associated with transcription of CELL CYCLE regulators such as CYCLIN KINASE INHIBITOR P21 and anti-apoptotic genes such as $BCL-$2 GENES. Stat5 is constitutively activated in many patients with acute MYELOID LEUKEMIA.

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